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Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:2 days ago · The Power Reactor Information System (PRIS), developed and maintained by the IAEA for over five decades, is a comprehensive database focusing on nuclear power plants worldwide If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS PRIS is a comprehensive database focusing on nuclear power plants worldwide and contains information on power reactors in operation, under construction, or those being decommissioned Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism Jan 12, 2026 · Propofol, known for its rapid onset, reliable patient response, and short duration of action, offers an attractive pharmacologic profile However, concerns for propofol-related infusion syndrome (PRIS) have limited its use in pediatric critical care PRĪS is a pediatric hospitalist research network Hospitalists are physicians whose clinical practice is the care of hospitalized patients Hospitalists are hospital-based physicians who want to ensure the system is delivering the highest quality of care for patients PRIS is an uncommon but serious complication that usually arises in patients undergoing prolonged propofol infusions, especially those receiving higher doses The precise mechanisms behind PRIS are intricate and remain under active investigation Propofol is widely used to sedate agitated patients in intensive care units However, it can cause a rare but fatal complication, propofol-related infusion syndrome (PRIS) The pathophysiology of PRIS is not clear, and there is no definitive diagnosis and treatment
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